After defeating Owen Shaw and his crew and securing amnesty for their past crimes, Dominic “Dom” Toretto, Brian O’Conner, and the rest of their team have returned to the United States to live normal lives again. Brian begins to accustom himself to life as a father, while Dom tries to help Letty Ortiz regain her memories. Meanwhile, Owen’s older brother, Deckard Shaw, breaks into the secure hospital the comatose Owen is being held in and swears vengeance against Dom, before breaking into Luke Hobbs’ DSS office to extract profiles of Dom’s crew. After revealing his identity, Shaw engages Hobbs in a fight, and escapes when he detonates a bomb that severely injures Hobbs. Dom later learns from his sister Mia that she is pregnant again and convinces her to tell Brian. However, a bomb, disguised in a package sent from Tokyo, explodes and destroys the Toretto house just seconds after Han, a member of their team, is killed by Shaw in Tokyo. Dom later visits Hobbs in a hospital, where he learns that Shaw is a rogue special forces assassin seeking to avenge his brother. Dom then travels to Tokyo to claim Han’s body, where he meets and races Sean Boswell, a friend of Han’s, who gives him personal items found at Han’s crash site.
Back at Han’s funeral in Los Angeles, Dom notices a car observing and chases after the vehicle, driven by Shaw. Both prepare to fight, but Shaw slips away when a covert ops team arrives. Its leader, who calls himself Mr. Nobody, offers to assist Dom in stopping Shaw if he helps him obtain the God’s Eye, a computer program that uses digital devices to track down a person, and save its creator, a hacker named Ramsey, from a mercenary named Jakande. Dom, Brian, Letty, Roman Pearce, and Tej Parker then airdrop their cars over the Caucasus Mountains in Azerbaijan, ambush Jakande’s convoy, and rescue Ramsey. The team then heads to Abu Dhabi, where a billionaire has acquired the flash drive containing the God’s Eye, and manage to steal it. With the God’s Eye, the team track Shaw, who is waiting at a remote factory, but they are ambushed by Jakande and his militants, and are forced to flee while Jakande obtains the God’s Eye. At his own request, Mr. Nobody is then left to be evacuated by helicopter. Left with no other choice, the team decides to return to Los Angeles to fight Shaw, Jakande and his men on the former’s home turf. Meanwhile, Brian promises Mia that once they deal with Shaw, he’ll dedicate himself to their family full-time.
While Jakande pursues Brian and the rest of the team with a stealth attack helicopter and drone, Ramsey attempts to hack into the God’s Eye while sharing her mobile between their vehicles. Hobbs, seeing the team in trouble, breaks out of hospital and destroys the drone. Ramsey then regains control of the God’s Eye and shuts it down. Meanwhile, Dom and Shaw engage in a one-on-one brawl on a parking garage, before Jakande intervenes and attacks them both, and Shaw is defeated when part of the parking garage collapses beneath him. Dom then launches his vehicle at Jakande’s helicopter, tossing a bag of grenades onto its skids, before he crash lands. Hobbs then shoots the bag of grenades from ground level, destroying the helicopter. When Dom remains unconscious, the team fears that he is dead. As Letty cradles Dom’s body in her arms, she reveals that she has regained her memories, and that she remembers their wedding. Dom regains consciousness soon after, remarking, “It’s about time”.
Later, Shaw is taken into custody by Hobbs and locked away in a secret, high-security prison. Meanwhile, at a beach, Brian and Mia play with their son while Dom, Letty, Roman, Tej, and Ramsey observe, with Dom acknowledging that Brian is better off retired with his family. Dom silently leaves, but Brian catches up with him at a stop sign. As Dom recalls his time with Brian, the two bid each other farewell, and drive off in different directions.