Following their successful Rio heist, Dominic “Dom” Toretto and his professional criminal crew have fled around the world: Dom lives with Elena; his sister Mia lives with Brian O’Conner and their son, Jack; Gisele and Han live in Hong Kong; and Roman and Tej live in luxury.
Diplomatic Security Service (DSS) agents Luke Hobbs and partner Riley Hicks investigate the destruction of a Russian military convoy by former British Special Forces soldier Owen Shaw’s crew. Hobbs persuades Dom to help capture Shaw by showing him a photo of the supposedly long-dead Letty Ortiz, Dom’s former lover. Dom and his crew accept the mission in exchange for amnesty, allowing them to return home to the United States.
In London, Shaw’s hideout is found, but this is revealed to be a trap, distracting them and the police while Shaw’s crew performs a heist at an Interpol building. Shaw flees by car, detonating his hideout behind him and disabling most of the police, leaving Dom, Brian, Tej, Han, Gisele, Hobbs, and Riley to pursue him. Letty arrives to help Shaw, shooting Dom without hesitation before escaping. Back at their headquarters, Hobbs tells Dom’s crew that Shaw is stealing components to create a deadly device, intending to sell it to the highest bidder. Meanwhile, Shaw’s investigation into the opposing crew reveals Letty’s relationship with Dom, but she is revealed to be suffering from amnesia.
Dominic’s crew learns that Shaw is connected to a drug lord imprisoned by Brian, Arturo Braga. Brian returns to the United States as a prisoner to question Braga, who says Letty survived the explosion that was thought to have killed her; Shaw took her in after discovering her amnesia. With FBI help, Brian is released from prison, regrouping with the team in London. Dom challenges Letty in a street racing competition; afterwards, he returns her cross necklace he had kept. After Letty leaves, Shaw offers Dom a chance to walk away, threatening to otherwise hurt his family; Dom refuses.
Tej tracks Shaw’s next attack to a Spanish NATO base. Shaw’s crew assaults a highway military convoy carrying a computer chip to complete his deadly device. Dom’s crew interferes while Shaw, accompanied by Letty, commandeers a tank, destroying cars en route. Brian and Roman manage to flip the tank before it causes further damage, resulting in Letty being thrown from the vehicle and Dom risking his life to save her. Shaw and his crew are captured, but reveal Mia has been kidnapped by Shaw. Hobbs is forced to release Shaw, and Riley, Shaw’s covert accomplice, leaves with him; Letty chooses to remain with Dom.
Shaw’s group board a large moving aircraft on a runway as Dom’s crew gives chase. Dom, Letty, and Brian board the craft; Brian rescues Mia, escaping in an onboard car. The plane attempts take-off, but is held down by excess weight as the rest of the team tether the plane to their vehicles. Gisele sacrifices herself to save Han from a henchman; Letty kills Riley and escapes to safety, but Dom pursues Shaw and the computer chip. As the plane crashes into the ground, Shaw is thrown from it, and Dom drives a car inside through the exploding plane, reuniting with his crew, and giving the chip to Hobbs to secure their pardons.
In the aftermath, Dom and the others return to the United States. Hobbs and Elena, now working together, arrive to confirm the crew’s freedom; Elena accepts that Dom loves Letty. As Roman says grace over the crew’s meal, Dom asks Letty if the gathering feels familiar; she answers no, “but it feels like home.”
A post-credits scene ensues: Reprising a scene from Tokyo Drift, Han flees from unseen enemies in a high-speed pursuit in Tokyo, when suddenly he is rammed by an oncoming car which has been covertly following the chase. The other car’s driver walks away from the scene after leaving Letty’s cross necklace by the crash site, and calls Dom as Han’s car fatally explodes: “You don’t know me… you’re about to.“